Clinical Significance of Germline BRCA Mutations

Inclusion Criteria

• •Families referred for genetic counseling consultation at Memorial Hospital
• •Individuals self-referred or physician referred for genetic counseling due to a concern about increased risk for breast cancer, regardless of family history or ethnic origin.
• •Individuals enrolled in MSK protocol 97-029 "Germline BRCA1 and BRCA2 mutations in Jewish Women Affected by Breast Cancer"
• •Individuals who present for genetic counseling consultation at Memorial Hospital after undergoing genetic testing at an outside institution.
• •Member of a family with breast cancer who wishes to provide a DNA sample for research purposes
• •Individuals enrolled on protocol 12-245 with germline variants in genes associated with risk for breast or ovarian cancer, or absent such variants in the presence of a family history or other phenotypic features of interest including but not limited to: triple negative breast cancer, early onset of disease, and/or synchronous or metachronous breast and ovarian cancer.