Trial of Aspirin and Arginine Restriction in Colorectal Cancer

Inclusion Criteria

• •Subjects must be 18-80 years of age with a history of surgically removed colon or rectal cancer, and have received treatment for their disease using drugs (adjuvant chemotherapy)
• •Subjects must have colon or rectal cancer with stage I, II, or III disease
• •Subjects should not have further treatment with radiation therapy. Subjects having already received adjuvant (i.e., post-operative) radiation therapy to the colon or rectum will be excluded. However, subjects receiving radiation therapy prior to surgery for rectal cancer are eligible for enrollment.
• •Subject's tumor must have been completely removed within the past 12 months, with first surveillance colonoscopy anticipated 12 weeks after study treatment start date (i.e. one-year after surgical removal).
• •Subjects must be in good physical status
• •If subjects are premenopausal and perimenopausal women, they must be using adequate birth control methods.
• •Subjects must have no history of another invasive cancer within 5 years
• •Subjects must have no further chemotherapy anticipated.
• •Subjects don't have special dietary requirements or additives. Subjects must not be consuming a diet that would preclude taking the study medication.
• •Subjects must have no concomitant use of calcium supplements (\> 520mg/day).
• •Subjects must have no history of abnormal wound healing or repair, or conditions that predispose to the same.
• •Subjects don't have personal history of colon resection of or inflammatory bowel disease.
• •Subjects must give informed consent via consent form approved by the local Human Subjects Committee (Institutional Review Board).
• •If subjects are taking aspirin 81mg by mouth daily they will be eligible
• •Subjects must have no history of allergies or adverse reactions to aspirin.
• •Subjects don't have documented history of gastric/duodenal ulcer within the last 12 months.