A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon

Exclusion Criteria

• •Patients who currently use nitrate medication or medications known to interact with nitroglycerin.
• •Patients who have an allergy to nitroglycerin or common topical gel ingredients.
• •Patients with a history of severe headaches.
• •Patients with an unstable medical problem.
• •Patients with cognitive or language difficulties that would impair their ability to complete assessment of pain instruments.
• •Patients who have had a recent heart attack or other uncontrolled heart condition.
• •Patients who have participated in an investigational drug study within four weeks of visit one.
• •Patients who have clinically significant abnormal lab values.
• •Patients who have had recent major abdominal, thoracic or vascular surgery.
• •Patients with interfering skin conditions.
• •Pregnant or nursing women or women unwilling to comply with contraceptive requirements.