Pegasys and Copegus for Asian Patients With Treatment-naive Hepatitis C Genotypes 6, 7, 8, 9

Exclusion Criteria

• •The subject will be excluded from entry if any of the following criteria apply:
• •Women who are pregnant or breast feeding.
• •Male partners of women who are pregnant.
• •Suspected hypersensitivity to interferon, PEG-interferon or Copegus.
• •Treatment with any investigational drug within 45 days of entry to this protocol.
• •Therapy with any systemic anti-viral, anti-neoplastic or immunomodulatory treatment greater than or equal to6 months prior to the first dose of study drug, except PEG-IFN alfa-2b and ribavirin. This includes amantadine, mycophenolate mofetil, thymosine alpha, viramidine, levovirin, supraphysiologic doses of steroids (greater than or equal to 10 mg/d for greater than or equal to 14 consecutive days of prednisone or equivalence) and radiation, exception: patients who have had a limited (greater than or equal to 7 day) course of acyclovir or valacyclovir for herpetic lesions more than 1 month prior to the first administration of test drug are not excluded.
• •Any other cause for the liver disease other than chronic hepatitis C including but not limited to:
• •* Co-infection with HBV
• •* Hemochromatosis (iron deposition greater than or equal to2+ or severe in liver parenchyma)
• •* Alpha-1 antitrypsin deficiency
• •* Wilson's disease
• •* Autoimmune hepatitis
• •* Alcoholic liver disease
• •* Significant obesity-induced liver disease (elevated ALT with BMI greater than or equal to 30)
• •* Drug-related liver disease
• •Hemophilia or any other condition that would prevent the subject from having a liver biopsy, including anticoagulant therapy.
• •Hemoglobinopathies (e.g., Thalassemia) with significant anemia.
• •History or other evidence of decompensated liver disease or a Child-Pugh score 6. Coagulopathy, hyperbilirubinemia, hepatic encephalopathy, hypoalbuminemia, ascites, and bleeding from esophageal varices are conditions consistent with decompensated liver disease.
• •Patients with history of hepatocellular carcinoma.
• •Any known preexisting medical condition that could interfere with the subject's participation in and completion of the protocol such as:
• •* A history of preexisting psychiatric condition, especially severe depression, or a history of severe psychiatric disorder, such as major psychoses, suicidal ideation and/or suicidal attempt are excluded. Severe depression would include the following: (a) subjects who have been hospitalized for depression, (b) subjects who have received electroconvulsive therapy for depression, or (c) subjects whose depression has resulted in a prolonged absence of work and/or significant disruption of daily functions. Subjects with a history of mild depression may be considered for entry into the protocol provided that a pretreatment assessment of the subject's mental status supports that the subject is clinically stable. The Investigator will formulate a management plan for each of the subjects that will become a part of the subject's medical record. The management plans may be developed in conjunction with a health care professional trained in psychology. For these subjects, the Investigator will review the subject's mental status at every visit.
• •* CNS trauma or active seizure disorders requiring medication.
• •* Significant cardiovascular dysfunction within the past 12 months (e.g., angina, congestive heart failure, recent myocardial infarction, severe uncontrolled hypertension or significant arrhythmia). Subjects with ECG showing clinically significant abnormalities.
• •* Poorly controlled diabetes mellitus.
• •* Chronic pulmonary disease (e.g., chronic obstructive pulmonary disease), documented pulmonary hypertension.
• •* Immunologically mediated disease (e.g., inflammatory bowel disease \[Crohn's disease, ulcerative colitis\], rheumatoid arthritis, idiopathic thrombocytopenia purpura, systemic lupus erythematosus, autoimmune hemolytic anemia, scleroderma, severe psoriasis, clinical cryoglobulinemia with vasculitis).
• •* Clinical gout.
• •* Any patient with an increased baseline risk for anemia (e.g. thalassemia other than thalassemia trait, spherocytosis, history of GI bleeding, etc) or for whom anemia would be medically problematic
• •* Patients in whom, in the judgment of the investigator, an acute decrease in hemoglobin by up to 4 g/dL (40 g/L) (as may be seen with ribavirin therapy) would not be well-tolerated.
• •* History of immunologically mediated disease (e.g., inflammatory bowel disease, idiopathic thrombocytopenic purpura, lupus erythematosus, autoimmune hemolytic anemia, scleroderma, severe psoriasis, rheumatoid arthritis etc.)
• •* History of major organ transplantation with an existing functional graft
• •Substance abuse, such as alcohol (greater than or equal to 80 gm/day), IV drugs and inhaled drugs. If the subject has a history of substance abuse, to be considered for inclusion into the protocol, the subject must have abstained from using the abused substance for at least 12 months. Stable subjects enrolled in a methadone maintenance program for at least one year may be enrolled if they are otherwise eligible and are monitored throughout the study for illicit drug use.
• •Subjects not willing to abstain from the consumption of alcohol.
• •Subjects with severe retinopathy (e.g. CMV retinitis, macular degeneration) or clinically significant retinal abnormalities.
• •Inability or unwillingness to provide informed consent or abide by the requirements of the study.
• •Any other condition, which in the opinion of the Investigators would make the subject unsuitable for enrollment, or could interfere with the subject participating in and completing the protocol.