About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Back to clinical trial search

TERMINATEDPhase 2/3NCT00573157

The Efficacy and Safety of Atacicept in Combination With Mycophenolate Mofetil Used to Treat Lupus Nephritis

The purpose of this study is to learn whether atacicept treatment leads to improvement in kidney function in subjects with active lupus nephritis in combination with mycophenolate mofetil (MMF) and co...

Lead sponsor: EMD Serono•12 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

EMD Serono

Collaborators

ZymoGenetics

Age

16 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Diagnosis of systemic lupus erythematosus (SLE) satisfying at least 4 out of the 11 American College of Rheumatology (ACR) criteria (Appendix B)
•Renal biopsy performed consistent with active International Society of Nephrology/Renal Pathology Society (ISN/PRS) class III or IV lupus nephritis

Exclusion Criteria

•Estimated glomerular filtration rate (GFR) less than or equal to (\<=) 30 milliliter per minute (mL/min) per 1.73 square meter (m\^2)
•Active central nervous system SLE deemed to be severe or progressive and/or associated with significant cognitive impairment
•Any treatment with MMF, azathioprine, or cyclophosphamide within the last 6 months, or known hypersensitivity to MMF or atacicept.
•Any prior treatment with abatacept, rituximab, belimumab, or other B cell modulating agents.

Related studies

RECRUITINGPhase 1/2

Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

NCT06434363 · Autoimmune Disorders, Systemic Sclerosis, and more

RECRUITINGPhase 2

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

NCT05538208 · Lupus Nephritis

RECRUITINGPhase 3

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis

NCT05126277 · Lupus Nephritis

RECRUITINGPhase 2

A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

NCT07015983 · Lupus Erythematosus, Systemic, Lupus Nephritis

RECRUITINGPhase 1/2

CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH

NCT06947460 · Refractory Lupus Nephritis, Systemic Sclerosis, and more

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 23, 2016Terms

Trial snapshot

StatusTERMINATED

PhasePHASE2/PHASE3

Enrollment6

Start dateDec 2007

Last updatedMar 23, 2016

Condition

Lupus Nephritis

Locations shown

Tulane University Hospital and Clinic Department of Internal Medicine

New Orleans, Louisiana

Northwest Louisiana Nephrology Research

Shreveport, Louisiana

Wayne State University Lupus Database Departments of Internal Medicine and Obstetrics & Gynecology Division of Rheumatology Wayne State University School of Medicine

Detroit, Michigan

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 23, 2016Data synced to Clareo: May 17, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions