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Apoptic Biomarkers of Periodontal Disease | Clinical Trials | Clareo Health

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COMPLETEDNCT00569075

Apoptic Biomarkers of Periodontal Disease

The goal of this study is to facilitate early diagnosis of gum disease. Proteins associated with cell death will be isolated from gum pockets of diseased and healthy patients and evaluated.

Lead sponsor: University of Michigan•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Michigan

Early detection of the progression of periodontitis is difficult because it typically relies on comparisons of clinical measurements made with a calibrated probe and nonstandardized radiographs over time. Both methods detect periodontal breakdown only after it has occurred. Therefore, considerable emphasis has been placed on identifying more specific and sensitive methods to diagnose and detect periodontal disease progression. The overall goal of this project is to determine whether specific apoptosis-associated proteins, specifically fibronectin (FN) fragments, caspase-3, soluble Fas, and soluble Fas ligand, sampled from gingival crevicular fluid (GCF) can be used as markers for periodontal disease progression.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Adults over age of 18
•Healthy or diagnosis of periodontitis

Exclusion Criteria

•Active treatment with anti-inflammatory agents such as NSAIDs or steroids and pregnant females

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 10, 2017Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment60

Start dateOct 2006

Last updatedMay 10, 2017

Condition

Locations shown

Michigan Center for Oral Health Research

Ann Arbor, Michigan

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 10, 2017Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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