A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction

Exclusion Criteria

• •Liver enzymes greater than two times normal
• •Any history of hepatitis
• •History of disorders requiring chronic treatment with steroids
• •Significantly abnormal ECG
• •Any prominent DSM-IV axis I disorders other than cocaine dependence
• •Any subject who presents as a danger to self or others in the opinion of the Principal Investigator
• •Concomitant use of methamphetamine as determined by self-reporting and verified by measurement of methamphetamine in urinary drug screen
• •Alcohol consumption greater than 4 drinks per day (1 Drink = 12 oz beer; 5 oz wine; 1.5 oz shot of liquor)
• •Any clinically significant laboratory test abnormalities
• •Use of any concomitant medication during the study that would interfere with study medications
• •Serum cortisol less than 3 µg/dl at any time before or during study
• •Treatment with an investigational product within 30 days prior to study enrollment
• •Currently seeking other forms of professional addiction treatment
• •Known allergic reaction to oxazepam or metyrapone
• •Lactose intolerance