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Gene Regulation by Thiazolidinediones | Clinical Trials | Clareo Health

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COMPLETEDPhase 4NCT00567593

Gene Regulation by Thiazolidinediones

The purpose of this study is to determine the effect of rosiglitazone on the genes of the colon

Lead sponsor: James Lewis•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

James Lewis

Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

The primary aim of the study is to examine the effect of rosiglitazone (Avandia) on gene regulation in colonic epithelium in the absence of pathologic acute and chronic intestinal inflammation. The secondary aims are to determine the effect of rosiglitazone (Avandia) therapy on T cell activation and cytokine expression in the absence of pathologic acute and chronic intestinal inflammation.

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Capable of giving informed consent
•Agrees to use a barrier method of birth control for the duration of the study

Exclusion Criteria

•History of inflammatory bowel disease
•Has taken prescription or over the counter medications in the two weeks prior to enrollment
•History of diabetes, heart failure, angina, hypertension, coronary heart disease, cancer, bleeding disorder, HIV, AIDS
•Fasting LDL \>160 mg/dl
•History of smoking in the year prior to enrollment
•Pregnant or breastfeeding

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: August 1, 2016Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE4

Enrollment12

Start dateOct 2007

Last updatedAug 1, 2016

Condition

Inflammatory Bowel Disease

Locations shown

University of Pennsylvania Clinical and Translational Research Center

Philadelphia, Pennsylvania

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 1, 2016Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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