Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Massachusetts General Hospital
With
Ortho-McNeil Janssen Scientific Affairs, LLC
Age
18–90
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Criteria to enter the study include males and females between the ages of 18-90 (females must be post menopausal) and a DSM-IV diagnosis of Major Depressive Disorder, Major Depressive Disorder with psychotic features, Bipolar Disorder, depressed type, or Schizoaffective Disorder, depressed type (19).
You may not be if
DSM-IV diagnoses of dementia and its subtypes
Substance use disorder (active use within the last 6 months)
Organic mental disorders; seizure disorder
Unstable physical disorder or physical disorder judged to significantly affect the central nervous system function
A heart rate of \<60
A systolic blood pressure \< 90
Heart block
Pre-existing sick-sinus
Chronic treatment with beta blockers
Any cardiac arrythmia
Hypotension
Coronary artery disease
Liver and renal function impairment
Urge incontinence, colitis Crohn's disease, GI motility disorders, asthma and COPD
Treatment with anti-cholinergic and cholinomimetic medications; and
Female patients who are pregnant.
Additionally, women subjects must be postmenopausal, surgically sterile, or using prescription oral contraceptives (e.g. estrogen-progestin combinations) , contraceptive implants (e.g. NorplantTM, DepoProveraTM ), or transdermally delivered contraceptives (Ortho EvraTM) before entry and throughout the study; and have a negative serum b-HCG pregnancy test at screening.
Note: Abstinence and the use of double barrier contraceptive methods are not acceptable in this study.
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