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Prospective, Randomized, Double-blind Study Assessing the Effects of Levetiracetam Compared to Placebo in the Prevention of Early Epileptic Seizures and Late Epilepsy in Patients With Severe Traumatic Brain Injury
Post-traumatic seizures can appear frequently after a severe traumatic brain injury. Two types of seizures are usually identified: early seizures during the week following the trauma and late epilepsy afterward. Several antiepileptic drugs are usually used to prevent early seizures but no treatment has demonstrated any preventive effect against late epilepsy. Levetiracetam is an antiepileptic drug usually used for the treatment of epileptic patients and has pharmacologic properties that could also be interesting for the prevention of post-traumatic epilepsy.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Neurologie - CHU Angers
Angers, France
Neurology - CHU Bordeaux
Bordeaux, France
Neurologie - CHU Caen
Caen, France
Neurochirurgie-CHU Grenoble
Grenoble, France
Neurology - CHU Rennes
Grenoble, France
Neurophysiologie Clinique - CHU Lille
Lille, France
Neurophysiologie clinique - CHU Lyon (Hôpital neurologique)
Lyon, France
Beurophysiologie clinique - CHU Marseille
Marseille, France
Epileptologie - CHU Montpellier
Montpellier, France
Neurologie - CHU Nancy
Nancy, France
Start Date
November 1, 2007
Primary Completion Date
December 1, 2009
Completion Date
May 1, 2010
Last Updated
June 21, 2012
23
ACTUAL participants
Levetiracetam
DRUG
Placebo
DRUG
Lead Sponsor
Rennes University Hospital
Collaborators
Data Source & Attribution
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