Gemcitabine Plus Erlotinib Versus Erlotinib Plus Gemcitabine Plus Oxaliplatin, in Pancreatic Cancer

Exclusion Criteria

• •Chronic diarrheic syndrome.
• •Uncontrolled brain metastases after radiation.
• •Liver infiltration over 50%.
• •Peripheral neuropathy ≥ 2.
• •No second primary malignancy within the past 5 years, except non-melanomas skin cancer or in situ carcinoma of the cervix.
• •No active uncontrolled infection.
• •Active cardiac disease : unstable angina or onset of angina within last 3 months, myocardial infarction within 6 months, congestive heart failure \> class II, cardiac ventricular arrhythmias requiring anti-arrhythmic therapy.
• •Women who are pregnant or lactating.