An Open, Randomised, Parallel Group Multicentre Study to Compare the Efficacy and Safety of Flutiform® pMDI vs Fluticasone pMDI Plus Formoterol DPI in Adolescent and Adult Subjects With Mild to Moderate-severe Persistent, Reversible Asthma

1. Near fatal or life-threatening (including intubation) asthma within the past year.

2. Hospitalization or an emergency visit for asthma within the past year.

3. History of systemic (oral or parenteral) corticosteroid medication within 1 month before the Screening Visit.

4. History of omalizumab use within the past 6 months.

5. History of leukotriene receptor antagonist use, e.g. montelukast, or theophylline within the past week.

6. Current evidence or history of any clinically significant disease or abnormality including uncontrolled coronary artery disease, congestive heart failure, myocardial infarction, or cardiac dysrhythmia. 'Clinically significant' is defined as any disease that, in the opinion of the Investigator, would put the patient at risk through study participation, or which would affect the outcome of the study.

7. In the investigators opinion a clinically significant upper or lower respiratory infection within 4 weeks prior to the Screening Visit.

8. Significant, non-reversible, active pulmonary disease (e.g., chronic obstructive pulmonary disease (COPD), cystic fibrosis, bronchiectasis, tuberculosis).

9. Known Human Immunodeficiency Virus (HIV)-positive status.

10. A smoking history equivalent to "10 pack years" (i.e., at least 1 pack of 20 cigarettes /day for 10 years or 10 packs/day for 1 year, etc.).

11. Current smoking history within 12 months prior to the Screening Visit.

12. Current evidence or history of alcohol and/or substance abuse within 12 months prior to the Screening Visit.

13. Subjects who have taken B-blocking agents, tricyclic antidepressants, monoamine oxidase inhibitors, astemizole (Hismanal), quinidine type antiarrhythmics, or potent CYP 3A4 inhibitors such as ketoconazole within the past week.

14. Current use of medications that will have an effect on bronchospasm and/or pulmonary function.

15. Current evidence or history of hypersensitivity or idiosyncratic reaction to test medications or components.

16. Receipt of an investigational drug within 30 days of the Screening Visit (12 weeks if an oral or injectable steroid).

17. Current participation in a clinical study

What this study is about