Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
GlaxoSmithKline
Age
18–55
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Healthy male and female subjects. Female subjects must be of non-child bearing potential.
Aged between 18-55 years inclusive
Non-smokers
Normal spirometry
A signed and dated written informed consent is obtained from the subject
The subject is capable of giving informed consent, which includes compliance with the requirements and restrictions listed in the consent form
Available to complete the study
The subject is greater than or equal to 50kg with a body mass index within the range 19.0 to 29.9 kg/m2 inclusive
Response to ipratropium bromide
You may not be if
Any clinically relevant and important abnormality identified at the screening medical assessment (physical examination/medical history), clinical laboratory tests, or ECG (12-lead or Holter)
A history of breathing problems
A mean QTc(B) value \> 450ms, the QTc(B) of the 3 screening ECGs are not within 10% of the mean, a PR interval outside the range 90-210ms or an ECG that is not suitable for QT measurements at screening
A history of elevated resting blood pressure or a mean blood pressure higher than 140/90 mmHg at screening
A mean heart rate outside the range 40-90 bpm inclusive at screening
History of use of tobacco- or nicotine-containing products within 6 months of screening, and/or positive urine cotinine test results at screening
Where participation in the study would result in donation of blood in excess of 500mL within a 56 day period at screening
The subject is currently taking regular (or a course of) medication, whether prescribed or not, including herbal remedies such as St John's Wort etc.
The subject has taken:
prescription medications for 14 days prior to first dose of study drug, or
Over-the-counter (OTC) medications/preparations (including herbal remedies, etc.) excluding simple analgesics for 48 hours prior to first dose of study drug,unless it is judged by the Investigator not to compromise the subject's safety or influence the outcome of the study.
The subject has participated in a study with a new molecular entity or any other trial within a period of 3 months prior first dose of study drug
The subject has tested positive for hepatitis C antibody (third generation enzyme immunoassay), hepatitis B surface antigen or HIV antibodies (if tested according to site SOP's) at screening.
The subject has tested positive for drugs-of-abuse at screening
The subject has tested positive for urine alcohol (including ethanol) at screening The detection of alcohol would not be an exclusion at screening but would need to be negative pre-dose and during the study
The subject is unable to use the DISKUS™ and/or HandiHaler inhaler devices correctly at screening
The subject has a suspected history of alcohol abuse within the six months previous to the screening visit
The subject has a known allergy or hypersensitivity to magnesium stearate, milk protein or the excipient lactose monohydrate, iodine, ipratropium bromide, tiotropium bromide, atropine and/or any of its derivatives
The subject has a significant clinical history of prostatic hypertrophy or narrow angle glaucoma
The subject has received an allogeneic bone marrow transplant
The subject has claustrophobia that may be aggravated by entering the whole body plethysmography cabinet
Clareo Health | Effect of GSK1160724 In Healthy Volunteers
