Safety and Tolerability of E5555 and Its Effects on Markers of Intravascular Inflammation in Subjects With Acute Coronary Syndrome

Exclusion Criteria

• •1. History of acquired or congenital bleeding disorder, coagulopathy or platelet disorder, or history of pathological bleeding within the last 6 months
• •2. History of intracranial bleeding, history of hemorrhagic retinopathy, history of recent ischemic stroke or transient ischemic attack, or known structural cerebral vascular lesion
• •3. Recent trauma, major surgery, Percutaneous coronary intervention or coronary artery surgery
• •4. Clinically significant haematological, hepatic or renal abnormalities
• •5. Patients with some specific ST-segment changes, severe congestive heart failure or uncontrolled cardiac arrhythmias at baseline
• •6. Recent significant (as determined by the investigator) cardiovascular events