BMS-646256 in Obese and Overweight Type 2 Diabetics

Exclusion Criteria

• •Pregnancy
• •Anti-diabetic medications other than baseline metformin or sulfonylurea monotherapy
• •History of myocardial infarction in the prior six months/ History of heart failure defined as New York Heart Association Functional Class I, II, III or IV/ History of symptomatic arrhythmia
• •Active hepatic disease/ Any documented muscle disease
• •History of multiple sclerosis/ Baseline history of tremors, ataxia, anxiety or dizziness
• •Seizures within the last year, stroke, and transient ischemic attack/ Known history of schizophrenia, dementia, or bipolar disorder as defined by DSM IV criteria.
• •Currently depressed subjects or a CES-D score greater or equal to 16 at the screening visit or at baseline (Day 1)/ History of suicide attempt or ideation
• •Previous history of surgical procedures for weight loss (e.g. stomach stapling, bypass)/ Weight loss greater than 5 kg in the prior 3 months