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We will test the hypothesis that there is a difference in effectiveness of oral quinine in comparison to artemether Lumefantrine in the treatment of uncomplicated malaria in children.
This study will be designed as an open randomized effectiveness study assessing the parasitological and clinical cure rates and adherence to oral quinine monotherapy in comparison to artemether-Lumefantrine. We will also describe some of the adverse events to the two drugs.The measurements will include age, sex, weight, hemoglobin levels on days 0, 7, 14 and 28, parasite density on days 0, 7, 14 and 28 and clinical examination findings. Adverse events will also be documented
Age
0 - 5 years
Sex
ALL
Healthy Volunteers
No
Mulago National Referral Hospital
Kampala, Central Region, Uganda
Start Date
September 1, 2007
Completion Date
April 1, 2008
Last Updated
October 5, 2007
302
ESTIMATED participants
artemether-lumefantrine
DRUG
Oral quinine
DRUG
Lead Sponsor
Makerere University
Collaborators
NCT07403643
NCT04767217
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT06036030