Pilot Study of Patients Chronic Hepatitis C in Co-infected HIV Patients Relapsers After Previous Therapies

Exclusion Criteria

• •Women with ongoing pregnancy or breast feeding
• •Positive test at screening for anti-HAV IgM Ab, HBsAg, anti-HBc IgM Ab, HBeAg
• •Hemochromatosis
• •Deficit of alfa-1 antitrypsin
• •Wilson disease
• •Alcoholic liver disease
• •Autoimmune hepatitis
• •Hepatitis by toxin exposures
• •Hepatitis by obesity
• •Hemoglobinopathy (e.g. thalassemia)
• •History or other evidence of bleeding from esophageal varices or other conditions consistent with decompensated liver disease
• •Hepatocarcinoma observed in the liver ecography.
• •History of severe psychiatric disease, especially depression. Severe psychiatric disease is defined as treatment with an antidepressant medication or a major tranquilizer at therapeutic doses for major depression or psychosis, respectively, for at least 3 months at any previous time or any history of the following: a suicidal attempt, hospitalization for psychiatric disease, or a period of disability due to a psychiatric disease
• •History of a severe seizure disorder or current anticonvulsant use
• •History of significant cardiac disease that could be worsened by acute anemia (e.g. NYHA Functional Class III or IV, myocardial infarction within 6 months, ventricular tachyarrhythmias requiring ongoing treatment, unstable angina)
• •Diabetes Mellitus
• •History of immunologically mediated disease (e.g., inflammatory bowel disease, idiopathic thrombocytopenic purpura, lupus erythematosus, autoimmune hemolytic anemia, scleroderma, severe psoriasis, rheumatoid arthritis)
• •History or other evidence of chronic pulmonary disease associated with functional limitation
• •Drug use within 6 months of 1st dose and excessive alcohol consumption.
• •Concomitant treatment with ddI
• •Male partners of women who are pregnant