Lead Sponsor

University of Toledo Health Science Campus

Age

18 - 45 years

Sex

FEMALE

Healthy Volunteers

No

•Adult female patients seeking medical attention for seizures
•Regular menstrual cycles
•At least 2 seizures per month
•Must be on at least one form of birth control other than abstinence
•Must be on a stable anticonvulsant regimen of at least one and not exceeding three anticonvulsants, and not be using any perimenstrual seizure medications of hormone preparations
•If taking benzodiazepines for therapeutic purposes, must be on a stable regular dose
•Must be willing to take at least 400mcg of folic acid a day while in the study
•Must be able to detect, count or record seizures

•Can not be pregnant or trying to become pregnant
•Can not have used hormonal birth control methods for at least 3 months prior to enrollment
•Can not have an allergy to Phenobarbital
•Can not have a history of non-epileptic seizures
•Can not have a know liver dysfunction or history of chronic hepatitis
•Can not have a history of neurological disorder or history of status epilepticus in the preceding year
•Can not ahve a physical or psychiatric condition which in the PIs opinion could compromise her ability to participate