National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Protocols 1, 2A and 3 HIV negative, healthy normal volunteers, age \> 18 years old.
Protocol 2B HIV-infected subjects, age \> 18 years old and documented to have HIV-1 infection for ≥ 6 months, being started on efavirenz by their health care provider.
You may not be if
Protocols 1, 2A and 3 Currently on an NNRTI, coronary artery disease, peripheral vascular disease, recent opportunistic infection (within two months), impaired fasting glucose (glucose \> 100 mg/dl) or diabetes, anemia (Hct \< 39), hypertension (BP \> 140/90 mmHg or on medication), blood pressure \<100 mmHg, renal disease (Creatinine \> 1.6), LFT \> 2x ULN, use of cGMP specific phosphodiesterase 5 inhibitors (e.g., sildenafil) within 7 days of study, history of adverse reaction to nitrates, use within 30 days of anabolic steroids, systemic glucocorticoids, growth hormone, niacin, antipsychotics, or lipid lowering medications. Women will be tested for pregnancy immediately prior to each inpatient study and excluded if pregnant
Clareo Health | HIV Antiretroviral Drugs and Metabolism
