Safety and Efficacy of Methoxyflurane for Treatment of Incident Pain

Exclusion Criteria

• •Subjects with a clinical condition that may, in the opinion of the investigator, impact on the subject's ability to participate in the study, or on the study results
• •Participants who have had IV sedation/opioid on previous BMB and who wish to receive IV sedation/opioid on this occasion or who in the opinion of the BMB operator would be advised to receive IV sedation/opioid on this occasion
• •Concomitant use of other investigational agents
• •Concomitant use of nephrotoxic agents such as gentamicin
• •Uncontrolled INR (\>4)
• •Personal or familial hypersensitivity to fluorinated anaesthetics
• •Personal or familial malignant hyperthermia
• •Respiratory rate of less than 10 per minute
• •Has previously received methoxyflurane
• •Known pre-existing renal or hepatic impairment
• •Compromised Renal Function (creatinine ≥ 1.5 x ULNR)
• •Compromised Liver Function (bilirubin ≥ 2.5 x ULNR)
• •Premedication with anxiolytic (e.g. midazolam, diazepam)
• •Dosed with breakthrough dose of analgesic that may contribute to control of pain during the planned procedure