Combination Therapy in Indian Visceral Leishmaniasis

Exclusion Criteria

• •Pregnant or breast-feeding women
• •Individuals seropositive to HIV or individuals with a serious concurrent infection such as tuberculosis or bacterial pneumonia.
• •Women of child-bearing age will be counseled about adequate birth control during and for three months after miltefosine treatment and provided with a satisfactory method of contra-ception.
• •Granulocyte count \< 1,000/mm3, hemoglobin \< 5 g/dL or platelet count \< 40,000/mm3
• •Hepatic transaminases or total bilirubin greater than three times normal
• •Serum creatinine \> 2.0 mg/dL
• •Prothrombin time \> 5 seconds above control
• •Inability of subject or guardian to provide written informed consent