DepoCyt for Active Lymphomatous or Leukemic Meningitis

Inclusion Criteria

• •Cytologically confirmed, or radiographic evidence for lymphomatous or leukemic meningitis. If the CSF cytology is negative, patients must have MRI/CT brain and clinical findings consistent with neoplastic meningitis.
• •Karnofsky Performance Score of 60 or above.
• •Age ≥ 18 years.
• •Patients must have adequate hematologic, renal and liver function. Laboratory
• •Absolute neutrophil count (ANC) ≥ 1,500/mm3 or white blood cell count \> 3,000/mm3
• •Platelet count ≥ 100, 000/mm3
• •BUN and serum creatinine must be ≤ 1.5 times upper limit of laboratory normal
• •Total and direct serum bilirubin must be ≤ 1.5 times upper limit of laboratory normal
• •SGOT and SGPT ≤ 3.0 times upper limit of laboratory normal
• •Alkaline phosphatase derived from liver ≤ 2.0 times upper limit of laboratory normal
• •No uncontrolled infection other than human immunodeficiency virus that is being treated with anti-retroviral therapy
• •Patients who have had prior CNS radiation, prior intrathecal methotrexate, and prior CNS prophylaxis with intrathecal or intravenous cytarabine or methotrexate are eligible
• •Written informed consent