The Mental Activity and eXercise Trial for Seniors

Exclusion Criteria

• •Evidence of dementia (based on self-report, physician diagnosis or score \< 19 on Telephone Interview for Cognitive Status)
• •Significant central nervous system disorder (Parkinson's disease, multiple sclerosis, ALS \[Lou Gerig's disease\])
• •Major, current psychiatric disorder (major depressive disorder, schizophrenia, bipolar disorder, post-traumatic stress disorder, obsessive-compulsive disorder, psychiatric hospitalization in past 20 years)
• •Major central nervous system event (stroke, transient ischemic attack/mini-stroke, seizure, or traumatic brain injury that has left a residual deficit)
• •Significant heart disease (severe congestive heart failure, severe aortic stenosis, cardiac arrest, uncontrolled angina)
• •Significant lung disease (requiring supplemental oxygen or oral or injected steroids)
• •Other condition that would make participation potentially dangerous (cancer requiring treatment in past 3 years, severe arthritis, history of cardiac defibrillation, dialysis)
• •Lack of physician approval
• •Severe hearing or visual impairment
• •History of learning disability
• •Starting prescription medication to enhance cognitive function (e.g., memantine, aricept)
• •Dependent in any basic activity of daily living (eating, dressing, bathing, toileting, getting out of bed/chair)
• •History of alcohol abuse/heavy alcohol use
• •History of drug abuse/heavy drug use
• •Currently enrolled in another research study
• •Fibromyalgia or tremor severe enough to prevent use of a computer mouse
• •Planning to travel \> 4 exercise class days during study period
• •Behaviors during screening or baseline visit that, in the judgement of research staff, are likely to present significant problems (e.g., uncooperative, anger, inappropriate physical contact)
• •Unable to perform neuropsychological evaluations
• •Unable to complete consent process