A Study To Assess The Safety And Tolerability Of GSK189075 When Given With A Total Daily Dose Of >/ 2000mg of Metformin

Exclusion Criteria

• •Type I Diabetes.
• •Treatment with insulin within 3 months prior to screening
• •History of diabetic ketoacidosis or lactic acidosis
• •Allergy or sensitivity to metformin or similar drugs or any medical conditions which prohibit metformin use
• •Excessive blood donation 56 days before the start of the study
• •Urinary tract or bladder infections within four weeks of study start
• •Alcohol abuse or illicit drug use within 12 months of study start
• •Receiving other investigational drugs or participating in other research trials within 30 of the study start
• •Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements with 7-14 days of study start
• •Live alone without regular, daily interactions with someone who can be an emergency contact