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Pharmacotherapy of Treatment-Resistant Mania | Clinical Trials | Clareo Health

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COMPLETEDPhase 3NCT00518947

Pharmacotherapy of Treatment-Resistant Mania

Verapamil has been found in some but not all studies to have antimanic activity. Therefore, we investigated the use of verapamil, alone or as an adjunctive treatment, in manic patients who did not res...

Lead sponsor: University of Pittsburgh•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Pittsburgh

Collaborators

National Institute of Mental Health (NIMH)

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•To be eligible for the study, patients were required to have a lifetime diagnosis of bipolar 1 or schizoaffective disorder, a current manic episode meeting DSM-IV criteria, and ratings \>/= 7 on the Raskin Severity of Mania Scale and \>/= 15 on the Bech-Rafaelsen Mania Scale.

Exclusion Criteria

•Patients were excluded if they had:
•A pattern of severe rapid-cycling in which the patient consistently failed to meet the duration criteria for discreet episodes of syndromal mania or depression according to DSM-IV
•Sustained drug or alcohol abuse within the past three years
•Schizophrenia
•Organic affective syndrome
•A presenting episode that was secondary to the effect of any pharmacologic agent
•The presence of significant medical illness that would preclude or unduly complicate the intended pharmacologic management of the episode
•In females, refusal to use appropriate contraception; or
•Pregnancy.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 25, 2011Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE3

Enrollment45

Start dateNov 1994

Last updatedFeb 25, 2011

Condition

Locations shown

University of Pittsburgh

Pittsburgh, Pennsylvania

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 25, 2011Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions