peripheral neuropathy grade \> 2

history of ischemic cardiopathy, congestive heart failure (NYHA\>2), arrhythmia, hypertension or significant valvulopathy

abnormal biological values

A therapy or a serious disease which could involve a risk for the patient or interfere with the aims of the study

patient who is pregnant, breast feeding or using inadequate contraception

concomitant therapy by a potentially neurotoxic drug

concomitant inclusion in another therapeutic trial which could interfere with the aims of the study

patient who for familial, sociological, geographical or psychological condition could not be followed correctly

Use of FACT-GOG/NTX Questionnaire in Peripheral Neurotoxicity & Validation of a French Version of This Questionnaire