Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCT

Inclusion Criteria

• •No fully or single-antigen mismatched sibling donor is available to donate stem cells.
• •Age \>15 and \<61
• •ECOG PS \< or equal to 2
• •Adequate renal function with serum creatinine \<2.0 mg/dl
• •Pulmonary diffusing capacity \>40% of predicted
• •Cardiac ejection fraction \>40% as measured by radionuclide wall motion study or echocardiography
• •No active liver disease. Total bilirubin must be \< or equal to 2.0 mg/dl. Alkaline phosphatase and AST must be less than three times the upper limit of normal. Patients with hepatitis C and active hepatitis B are eligible only if a liver biopsy is performed and there is \< or equal to grade 2 inflammation. Patients wtih a history of HBV infection should be tested for HBeAg, antiHBe and HBV DNA (quantitative). Patients with active HBV viral replication should receive anti-viral therapy.
• •Negative serology for the human immunodeficiency virus (HIV)
• •Available HLA-matched donor (see HLA compatibility requirements below)
• •Signed informed consent from the recipient