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Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery
One-lung ventilation; organ protection; volatile anesthetics One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study: 1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse? 2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium. * Trial with immunomodulatory product / biological
Age
18 - 75 years
Sex
ALL
Healthy Volunteers
No
University Hospital of Zurich
Zurich, Switzerland
Start Date
October 1, 2004
Primary Completion Date
September 1, 2007
Completion Date
September 1, 2007
Last Updated
September 15, 2010
76
ESTIMATED participants
Sevoflurane/propofol
DRUG
Lead Sponsor
University of Zurich
NCT07465510
NCT07258875
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