1. Those in whom the time of injury is unknown

2. Those with any 2 readings of systolic blood pressure of \<90 prior to enrollment

3. Those who are known to have legal Do Not Resuscitate (DNR) orders in place prior to enrollment.

4. Those receiving CPR prior to enrollment

5. Known incarcerated individuals

6. Pulse ox reading of \< 90 prior to enrollment

7. Status epilepticus prior to enrollment

8. Penetrating head trauma

Non-Interventional F-Two Isoprostane Trial (NIFTI)