Finding studies
Finding studies
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Lead
CABYC
With
OBJECTIVES The objectives of this clinical trial are the following: * Main objective of the study: Overall response rate obtained after R-CHOP regime followed by Alemtuzumab consolidation as second line therapy * Secondary objectives * Determine the molecular complete response rate after R-CHOP regimen * Determine the efficacy of Alemtuzumab in response improvement after R-CHOP regimen: conversion of PR to CR and of MRD+ to MRD-. * Applicability (toxicity profile) of Alemtuzumab consolidation therapy. * As additional objectives will be considered: 1. Prognostic value of several biological variables (ZAP-70 and cytogenetics) having influence on the response 2. Response duration 3. Progression free survival 4. Overall survival
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted