Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johann Wolfgang Goethe University Hospital
Bronchial methacholine challenge is well established in asthma diagnostic and research purposes. ATS guidelines provide a short five-breath dosimeter protocol using a five-step dilution schedule. The Viasys APS system enables a feasible and less time consuming provocation with incremental dosages. In 48 young adults with bronchial hyperreactivity (BHR) the ATS-protocol with a five-step protocol using a single dilution of 16 mg/ml methacholine should be compared.
Age
12–45
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Informed consent
Age 12-45 years
Known bronchial hyperreactivity
You may not be if
Age \< 12 \> 45 years
Clinical asthma requiring regular inhalation
Vital capacity \< 80%
FEV1 \< 75%
Chronic disease conditions or infections
Pregnancy
Inhalative or systemic steroid use
Substance abuse
Incapability of understanding the study's purpose and performance
