Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Diagnosis of epithelial solid tumors of any of the following sites or types:
• •* Lung (closed to accrual as of 4/2/2009)
• •* Renal
• •* Prostate
• •* Breast (closed to accrual as of 4/2/2009)
• •* Sarcoma (closed to accrual as of 4/2/2009)
• •* Colon (closed to accrual as of 4/2/2009)
• •* Liver(closed to accrual as of 4/2/2009)
• •* Pancreatic (closed to accrual as of 4/2/2009)
• •* Bone (closed to accrual as of 4/2/2009)
• •* Head and neck (closed to accrual as of 4/2/2009)
• •* Melanoma (closed to accrual as of 4/2/2009)
• •* Carcinoma of unknown primary (closed to accrual as of 4/2/2009)
• •Advanced or metastatic disease
• •Ineligible for or unwilling to undergo surgical resection
• •Eligible for cryotherapy but not expected to be cured by cryotherapy alone
• •PATIENT CHARACTERISTICS:
• •ECOG performance status 0-2
• •Life expectancy \> 3 months
• •Creatinine \< 2.5 mg/dL
• •Platelet count \>75,000/mm³
• •INR\< 1.5
• •No known HIV positivity
• •No active, uncontrolled infection
• •Not pregnant
• •Negative pregnancy test
• •Women of childbearing potential must practice adequate contraception
• •No debilitating medical or psychiatric illness that would preclude giving informed consent or receiving optimal treatment and follow-up
• •PRIOR CONCURRENT THERAPY:
• •See Disease Characteristics