A Dose Escalation Study of E7107 Administered Intravenously on Days 1 and 8 Every 21 Days to Patients With Solid Tumors

Exclusion Criteria

• •Patients with the following characteristics will not be eligible for the study.
• •1. Symptomatic or progressive brain tumors or brain or leptomeningeal (CNS) metastases requiring clinical intervention, except if they have completed local therapy and have discontinued the use of corticosteroids for this indication for at least two weeks before starting treatment with E7107.
• •2. Any of the following laboratory parameters:
• •1. hemoglobin \< 9 g/dL (5.6 mM)
• •2. neutrophils \< 1.5 x 10\^9/L
• •3. platelets \< 100 x 10\^9/L
• •4. serum bilirubin \> 25 μM (1.5 mg/dL)
• •5. liver function tests (defined as AST and ALT) with values \> 3 x ULN (5 x ULN if liver metastases are present)
• •6. serum creatinine \> 1.5 x ULN or creatinine clearance \< 40 mL/min.
• •3. Positive history of HIV, active hepatitis B or active hepatitis C or severe/uncontrolled intercurrent illness or infection.
• •4. Clinically significant cardiac impairment or unstable ischemic heart disease (greater than Class II according to New York Heart Association (NYHA) classification) including a myocardial infarction within six months of study start.
• •5. Bleeding or thrombotic disorders, or using therapeutic dosages of anticoagulants
• •6. History of alcoholism, drug addiction, or any psychiatric or psychological condition which, in the opinion of the Investigator, would impair study compliance.
• •7. Women who are pregnant or breast-feeding. Women of childbearing potential with either a positive serum pregnancy test at screening, a positive urine pregnancy test at the beginning of any cycle, or no pregnancy test. Women of childbearing potential unless using two forms of contraception, one of which must be a barrier method. Postmenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential.
• •8. Fertile men and fertile women who are not willing to use contraception, or fertile men or fertile women with a partner who is not willing to use contraception
• •9. Patients with a marked screening or baseline prolongation of QT/QTc interval using the Fridericia formula (ie, repeated demonstration of a QTc interval \> 450 msec); a history of additional risk factors for Torsade de Pointe (e.g., heart failure, hypokalaemia, history of Long QT Syndrome).
• •10. Patients who have had radiation to \>= 25% of their bone marrow (e.g., pelvic radiation).
• •11. Patients who have a history of previous Grade 2 or higher hypersensitivity to pladienolide B or derivatives and excipients of the formulation
• •12. Patients with significant comorbid disease or condition, which in the Investigator's opinion would exclude the patient from the study
• •13. Patients who have received an organ allograft ie, requiring immunosuppressive therapy
• •14. Beginning two weeks prior to dosing, patients are not allowed to take drugs that are strong CYP inhibitors (including grapefruit juice and herbal supplements) or inducers (including herbal supplements), or are metabolized by cytochrome P (CYPs) and known to have a narrow therapeutic window.
• •15. After MTD has been reached: Second malignancy within the past 5 years, except for carcinoma in situ of the cervix, basal cell carcinoma of the skin.