Regenecare® Wound Gel in Treating Rash in Patients Receiving Cetuximab or Other Epidermal Growth Factor Receptor Inhibitor Therapy for Cancer

OBJECTIVES: Primary * Determine the efficacy of Regenecare® wound gel in alleviating pain and itching in patients who develop an acneiform rash while undergoing treatment with cetuximab or other EGFR inhibitor therapy for cancer. Secondary * Determine the efficacy of this drug in reducing the severity of rash in these patients. * Determine the efficacy of this drug in reducing the redness and appearance of the rash in these patients. * Determine the tolerability of this drug in these patients. OUTLINE: This is a prospective study. * Observation: Patients undergo evaluation by full-face photography prior to development of skin rash (baseline). While undergoing concurrent cancer therapy, patients self-monitor for the appearance of an acneiform rash. Upon initial onset of rash, patients proceed to treatment. * Treatment: Patients apply topical Regenecare® wound gel to the face ≥ 4 times daily. Treatment continues for 4 weeks in the absence of unacceptable toxicity. Patients are evaluated weekly by facial examination, full-face photography, and patient satisfaction questionnaires.