Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Pathologically diagnosed glioblastoma multiforme or other malignant glioma
• •* Recurrent disease
• •Must have received prior temozolomide
• •PATIENT CHARACTERISTICS:
• •Karnofsky performance status 60-100%
• •Granulocyte count ≥ 1,500/mm³
• •Platelet count ≥ 100,000/mm³
• •SGOT ≤ 2.5 times upper limit of normal (ULN)
• •Creatinine ≤ 2 times ULN
• •Bilirubin ≤ 2 times ULN
• •No other active malignancy except for cervical carcinoma in situ or basal cell carcinoma of the skin
• •No serious medical or psychiatric illness that, in the opinion of the investigator, would preclude study treatment
• •No medical condition that precludes swallowing pills
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective contraception
• •PRIOR CONCURRENT THERAPY:
• •See Disease Characteristics
• •Recovered from all prior therapy