Effect of HSV-2 Suppressive Therapy on Sexual Behavior

Exclusion Criteria

• •Pregnancy or intention to become pregnant within the next year
• •Suppressive therapy with acyclovir, valacyclovir, or famciclovir within 2 weeks of enrollment/randomization
• •6 or more symptomatic herpes recurrences in the prior 12 months or in the 12 months prior to starting suppressive therapy if on suppressive therapy during the prior 12 months
• •HIV seropositive or known immunocompromising medical condition. HIV negative test must be performed within 60 days of Visit 1 (enrollment/randomization). For current or former participants in HIV vaccine clinical trials for whom HIV vaccine-induced seropositivity potentially leading to vaccine study unblinding may be a concern, a report from the Seattle HVTU documenting that the participant is HIV uninfected based on HIV testing done within 60 days of Visit 1 will be accepted in lieu of HIV testing done at our clinic.
• •Intention to move from the Seattle area within the next year
• •Known allergy, intolerance, or medical contraindication to acyclovir
• •Inability to understand, speak, and read English