current use of bisphosphonates, PTH-analogs, estrogen, SERM, p.o. steroids or use of any of these agents last year

serum creatinin \>110 umol/L

systolic blood pressure \>175 mmHg or diastolic blod pressure \>105

serious disease (heart failure, angina pectoris, myocardial infarction, diabetes, mental reduction, granulomatous disease like sarcoidosis, cancer)

kidney stone

serum calcium \> 2.55 mmol/L

suspect primary hyperparathyroidism with serum calcium \>2.50 mmol/L combined with PTH \> 5.0 mmol/L or serum calcium \> 2.45 mmol/L combined with PTH \>= 7.0 pmol/L

High Dosage Vitamin D and Osteoporosis

What this study is about