Phase 1-2 of a CpG-Activated Whole Cell Vaccine Followed by Autologous Immunotransplant for MCL

Study treatment is a complex set of steps of research procedures and regular medical care. By using a participant's cancer cells as an immungen, the study hopes to improve freedom from molecular residual disease (MRD). PRIMARY OBJECTIVE Freedom from molecular residual disease at 1-year post-autologous transplant. SECONDARY OBJECTIVE Time To Clinical Progression (TTP) This study has 2 research agents, PF-03152676 and CpG-MCL Vaccine. PF-03152676 is a synthetic DNA molecule, 24 nucleotides in length with a nuclease-resistant phosphorothioate backbone. It is an immunostimulatory, single-stranded oligodeoxynucleotide (oligo-DNA) containing unmethylated cytosine and guanine (CpG) motifs and synthesized with a nuclease-resistant phosphorothioate backbone. PF-03512676 acts as an agonist of human Toll-like receptor 9, leading to activation of antigen-presenting cells and a cascade of anti-tumor immune reactions. CpG-MCL Vaccine is the primary study agent. It is prepared by dissociating a participant's harvested tumor cells into a single-cell suspension, and culturing them with PF-03152676 for 72 hours at 37 degrees C, 5% CO2 to allow for up-regulation of antigen-presenting and co-stimulatory molecules, then irradiated to 200 Gy to destroy any remaining cancer propagating ability. The study procedure is summarized as 12 steps, listed below. * Step 1. Undergo excisional tumor biopsy or apheresis to obtain tumor cells, which will be used to generate the CpG-MCL vaccine . * Step 2. Receive standard induction chemotherapy (regular medical care). * Step 3. Once in remission, receive 3 vaccinations of CpG-MCL Vaccine over 3 weeks. With each CpG-MCL vaccination, a concurrent subcutaneous injection of PF-3512676 is administered as an adjuvant. * Step 4. About 4 weeks later, receive rituximab 375 mg/m² to minimize any residual tumor. * Step 5. Apheresis procedure to harvest the CpG-MCL Vaccine-primed T-cells. Each collection is \~1 x 10e10 CD3+ T-cells. * Step 6. High-dose cytoxan and filgrastim to mobilize peripheral blood progenitor cell (PBPC). * Step 7. Undergo separate apheresis procedure to harvest PBPC). * Step 8. Receive myeloablative chemotherapy (regular medical care). * Step 9. Receive PBPC infusion (also known as autologous hematopoietic cell transplant, AHCT). * Step 10. Within 3 days of AHCT (but typically 1 day), receive infusion of CpG-MCL Vaccine-primed T-cells, followed within 1 hour by a with 4th vaccination with CpG-MCL Vaccine (1st booster vaccination). * Step 11. After hematopoietic recovery, receive 5th vaccination with CpG-MCl (2nd booster vaccination). * Step 12. Monitor participants for general health and disease status through at least 3 years.