Locally advanced or metastatic adenocarcinoma of the pancreas, confirmed by histology or cytology.
No prior chemotherapy for pancreatic cancer.
Performance status 0-2 (ECOG scale).
Age ≥ 18 y.
Adequate hematologic function (ANC ≥ 1500/mm³, platelet count ≥ 100,000/mm³).
Adequate hepatic function (total bilirubin ≤ 2.0xUNL and AST, ALT and AP ≤ 5.0xUNL)
Adequate renal function (creatinine ≤ 2.0).
Signed informed consent.
You may not be if
A history of treated or active central nervous system involvement by the tumor or active neurological disease.
Prior radiation. Patients with disease outside the irradiation field or documented disease progression of previously irradiated disease are eligible.
Unstable medical condition, including uncontrolled diabetes mellitus or hypertension, active infection, unstable CHF, uncontrolled arrhythmias or unstable coagulation disorders.
