Study the Role of Positron Emission Mammography in Pre-surgical Planning for Breast Cancer

Inclusion Criteria

• •1. Women who are 25 years of age or older
• •2. Newly diagnosed core-biopsy proven breast cancer
• •3. Has current mammography of all study breasts (within prior 3 months), including magnification views of suspicious calcifications (if any)
• •4. Recent clinical breast examination (within prior 3 months)
• •5. Has had full diagnostic workup with breast ultrasound (within prior 3 months) as indicated by mammographic and/or clinical findings
• •6. Has had percutaneous biopsy of all relevant suspicious findings on mammography, clinical examination, and ultrasound
• •7. After full diagnostic workup, participant is likely to be a candidate for breast conserving surgery.
• •8. No contraindications to breast MRI:
• •* No pacemaker, aneurysm clip, or other implanted magnetic or ferromagnetic device;
• •* No claustrophobia that cannot be controlled by medication with valium, ativan, or other sedative under her physician's orders;
• •* Has intravenous access;
• •* Weight \< 300 lbs;
• •* Physically able to tolerate positioning in the MRI scanner.
• •9. Agrees to undergo follow-up MRI or PEM at 6 months and/or MRI-guided vacuum-assisted biopsy, US-guided core biopsy, or PEM-guided biopsy if needed based on results of the MRI or PEM examination
• •10. Has signed study-specific consent form
• •11. Subject agrees to undergo a contrast-enhanced MRI and PEM scan within five business days of each other, prior to surgery.