Predictive Markers of Glitazone Efficacy in Diabetic Patients - Pilot Study

Inclusion Criteria

• •1. Male subjects aged 18 to 65 years.
• •2. Eligible subjects must be free from clinically significant illness or disease (other than type 2 diabetes)with the exception of chronic stable-treated hypertension (BP\<160/90, and \>90/50), thyroid disease (TSH in the normal reference range) and/or dyslipidaemia.
• •3. BMI must be \> or = 25kg/m2 to \< or = 40kg/m2,
• •4. HbA1c between 7and 10%, fasting blood glucose above 7mmol/L (fasting means greater or = 8 hours prior to screening).
• •5. On diet alone or diet plus metformin (GSK data indicate that the latter group more faithfully reflect the behaviour of 'naive' patients than those who have been washed off prior medications)for at least 1 month.
• •6. On stable doses of anti-hypertensive medication, thyroid hormone replacement and statin therapy as required.