Have uncontrolled high blood pressure, uncontrolled diabetes mellitus, or other serious underlying medical condition not compatible with study entry.

Have a life expectancy \< 3 months

Received prior treatment with a camptothecin (topotecan, CPT-11, or investigational camptothecins).

Received prior treatment with any platinum agent other than cisplatin or carboplatin.

Received prior radiation therapy to greater than one-third of the hematopoietic sites (one-third of the pelvis and axial skeleton combined).

Karenitecin Versus Topotecan in Patients With Advanced Epithelial Ovarian Cancer