Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma

Inclusion Criteria

• •Subjects must have a clinical diagnosis of moderate to severe melasma
• •Subjects willing to undergo biopsy four times throughout the study, two biopsies at baseline (one in a melasma involved area and one in a non-involved area). The third and fourth biopsies will be performed at 3 months and 6 months, respectively; in order to avoid variability in histopathological findings,
• •Subjects must have substantial melasma involvement of the cheeks and be willing to have the same general site biopsied at the baseline, month 3 and month 6 visits.