Impact of Switching to Continuous Release Dopamine Agonists

Inclusion Criteria

• •Subjects who are male or female and are aged 55 and older.
• •Subjects and/or their legal guardians must be able and willing to give informed consent.
• •Subjects must be on stable doses of pramipexole for greater than 4 weeks duration prior to screening.
• •Subjects who are female must be non-pregnant and non-nursing. Women of Child-Bearing Potential (WOCBP) must use a reliable method of contraception (e.g., oral contraceptive or long-term injectable or implantable hormonal contraceptive, double-barrier methods, such as condom and diaphragm, condom and foam, condom and sponge or intra-uterine devices) and have a negative serum pregnancy test at screening. Women are considered to not be of child-bearing potential if they have been surgically sterilized (physician-documented hysterectomy or tubal ligation) or if they are post-menopausal.
• •Subjects must have a clinical diagnosis of Parkinson's based on the presence of at least 2 of the 3 cardinal criteria - rest tremor, bradykinesia, rigidity - and no obvious history of head trauma, stroke, infectious, structural, or metabolic abnormality consistent with an alternative diagnosis to Parkinson's disease.
• •Evidence of one or more of the following symptoms: somnolence (ESS score ≥ 9), cognitive decline (MMSE \< 24 ± presence of hallucinations (NPI-Q), peripheral edema (present by objective physical exam with baseline ankle and calf circumference measured in centimeters).