An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME)

Inclusion Criteria

• •Subjects must meet all of the following laboratory criteria:
• •* HDL-C \<40 mg/dL for men and \<50 mg/dL for women.
• •* LDL-C ≥130 mg/dL but \<250 mg/dL.
• •* TG \<350 mg/dL.
• •* Creatine phosphokinase (CPK) \< 3 x upper limit of normal (ULN).
• •* Alanine aminotransferase (ALT); serum glutamic pyruvic transaminase \[SGPT\] and aspartate aminotransferase (AST); serum glutamic oxaloacetic transaminase \[SGOT\] \< 1.3 x ULN.
• •Subjects must also be reasonably compliant with the Therapeutic Lifestyle Changes (TLC) diet during the 4 to 5 week Screening Period prior to randomization (and be willing to comply for the duration of the study).