History of non-response to paroxetine

Patients who have been previously treated with agomelatine

History of bipolar disorder (I or II), schizophrenia, schizoaffective disorder, eating disorder, or obsessive compulsive disorder

Any current Axis I disorder other than major depressive disorder which is the focus of treatment

Substance or alcohol abuse in the last 30 days, dependence in the last 6 months

Use of any psychoactive medication after the screening visit

Female patients of childbearing potential who are not using effective contraception

A Placebo- and Paroxetine-controlled Study of the Efficacy, Safety and Tolerability of Agomelatine (25 or 50 mg) in the Treatment of Major Depressive Disorder (MDD)