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COMPLETEDNCT00450151

Platelet Activation Markers in Pediatric Cardiac Surgery

In this study the focus will be on correlating the levels of platelet activation markers (proteins that are released when blood cells are activated)to the duration of cardiopulmonary bypass, temperatu...

Lead sponsor: Weill Medical College of Cornell University•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Weill Medical College of Cornell University

This research is being done because we would like to learn more about platelet dysfunction in children undergoing cardiopulmonary bypass. It has been an established fact that cardiopulmonary bypass causes dysfunction in platelets. Activation of platelets during cardiopulmonary bypass is implicated as being a major factor in causing platelet dysfunction. For all participants, approximately 3.15 ml of blood will be collected in special tubes called CTAD tubes, before and after cardiopulmonary bypass (6.30ml in total). This amount of blood draw is well within the guidelines of NIH (National Institute of Health). Enzyme-linked immunosorbent assay (ELISA) will be performed using this plasma to make quantitative assessment of Platelet factor 4 and Transforming growth factor beta.

Age

0 - 7 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Patients scheduled to have surgery involving cardiopulmonary bypass for congenital cardiac abnormalities.
•Age: Newborn to 7 years
•Gender: male and female

Exclusion Criteria

•Emergency surgery
•Weight less than 3 kg
•Age greater than 7 years
•Patients with low platelet counts (\<100,000)
•Patients on medications that are known to interfere with platelet function such as prostacyclins, non-steroidal anti-inflammatory drugs, plavix.
•Patients whose parents not willing to give consent

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 1, 2012Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment10

Start dateFeb 2007

Last updatedMar 1, 2012

Condition

Coronary Disease

Locations shown

NewYork-Presbyterian Hospital-Weill Cornell Medical College

New York, New York

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 1, 2012Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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