Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis

Exclusion Criteria

• •Evidence of infectious diarrhea
• •Celiac disease
• •Endoscopic-histologic findings, which may have caused diarrhea
• •History of partial colonic resection
• •Diarrhea as a result of the presence of other symptomatic organic disease of the gastrointestinal tract
• •Active colorectal cancer or a history of colorectal cancer
• •Severe co-morbidity substantially reducing life expectancy
• •Abnormal hepatic function or liver cirrhosis (ALT, AST or AP \>= 2 x ULN)
• •Abnormal renal function (Cystatin C \> ULN)
• •Active peptic ulcer disease, local intestinal infection
• •Asthma, diabetes mellitus, infection, osteoporosis, glaucoma, cataract, or cardiovascular disease if careful medical monitoring is not ensured
• •Hemorrhagic diathesis