Efficacy and Safety of TMS for the Preemptive Treatment of Migraine With Aura

Exclusion Criteria

• •Women who are pregnant or breastfeeding
• •Routinely experiences any other type of headache that would confound discrimination from migraine headache with aura
• •Have migraine with prolonged aura \> 60 minutes
• •Have headaches due to other underlying pathology
• •Have headaches related to head or neck trauma
• •Overuse headache medications:
• •Has an intracranial metallic or Transcranial Magnetic Stimulation (TMS) implant or other metallic implants
• •Has cardiac pacemaker or any other implanted electronic device
• •Has any known history of alcohol abuse, drug dependency, or significant psychiatric illness in the previous 12 months
• •Having any medical condition, including but not limited to: clinically significant renal or hepatic disease; uncontrolled hypertension; clinically significant coronary vascular disease not stable for the past 6 months; personal or family history of seizures or taking medications for seizures or drugs that may lower seizure threshold, cerebral vascular ischemia; infarct; hemorrhage, or other central nervous system disease (e.g., multiple sclerosis, amyotrophic lateral sclerosis); unstable metabolic disease, hypoglycemia or diabetes; malignancy within the past 5 years excluding cutaneous basal cell carcinoma; tuberculosis
• •Has participated in any other investigational study within the previous 30 days.
• •Cannot place the device within 1 cm of the scalp.