Consecutive adults with primary open-angle glaucoma (POAG) who exhibit a mean untreated IOP greater than 23 m Hg at baseline (10:00).

Patient has POAG and is older than 29 years

The IOP without treatment is greater than 23 mm Hg and lower than 38 mm Hg at baseline (2 readings at 10:00)

Patient can be safely washed out without risk for significant deterioration

Distance best corrected Snellen visual acuity better than 1/10

Patient can understand the instructions and comply to medications

Open normal appearing angles

24-hour Intraocular Pressure Control With Travoprost/Timolol Fixed Combination Versus Travoprost